IS4EU-1_DR (DF0002393)

Autonomous IS4EU DNA transposon from zebrafish


DNA transposons from the IS4EU superfamily are characterized by the TA target site duplications. These transposons are wide spread in metazoans, including fish, frogs, lancelet, sea urchins, sea squirts, insects and cnidarians. Autonomous IS4EU transposons encode two proteins: the IS4EU-TR transposase, which is similar to the IS4-like bacterial transposases, and the ISEU-EX DNA exonuclease. Based on the conservation of both proteins in highly divergent transposons, is is clear that they are necessary for transpositions. IS4EU-1_DR is a consensus sequence of a very young family of autonomous IS4EU transposons that were active in the zebrafish genome in a last few million years. The IS4EU-1_DR transposon is characterized by 11-bp imperfect terminal inverted repeats, TA target site duplications, and it encodes two proteins: (i) the 464-aa transposase, IS4EU-1_DR1p, composed of the THAP DNA-binding domain and catalytic "DDE" domain, which is conserved in all IS4EU transposases, and (ii) the 505-aa IS4EU-1_DR2p exonuclease. Questions and comments send to Vladimir Kapitonov.


Accession Name Wikipedia
Type DNA Transposon Article
Class Cut and Paste
Superfamily PIF-ISL2EU

Hit Statistics

The model is 5004 positions long. The average length of non-redundant hits to the model is 259.6. This table shows the number of hits above score thresholds:

Species Gathering Trusted
non-redundant all hits non-redundant all hits
Danio rerio 151 76089 42 39468

External Database Links

  • Repbase : IS4EU-1_DR [Requires Repbase registration]