PiggyBac DNA transposon, Looper subfamily
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Looper encodes a protein similar to the transposase from IFP2 (aka PiggyBac), a DNA transposon first identified in the cabbage looper moth (J04364.2). There are about 200-500 copies of Looper preserved in the human genome. Most of them are severely damaged by mutations since Looper is a relatively old element. There is 80% average nucleotide identity between Looper's copies and the consensus sequence. Looper belongs to the TTAA superfamily of DNA transposons in mammals. Hallmarks of this superfamily are TTAA target site duplication and short terminal inverted repeats, including 5' and 3' terminal CCC and GGG, respectively. Activity of the protein encoded by the Looper-like elements could be related to multiple transpositions of the non-autonomous elements MER75 and MER85 in the human genome. The consensus sequence may be incomplete.
|Class||Cut and Paste|
Number of matches to this model that meet the "Gathering" threshold and more stringent "Trusted" threshold. For each threshold, two numbers are shown: (1) the number of matches to this model after removing redundant hits to other models ("non-redundant"), and (2) the total number of matches above threshold, including those with better scoring matches to other models ("all hits").
The model is 1557 positions long. The average length of non-redundant hits to the model is 502.5. This table shows the number of hits above score thresholds:
|non-redundant||all hits||non-redundant||all hits|
External Database Links
- Repbase : LOOPER [Requires Repbase registration]