HERVE (DF0000174)

Internal region of an ERV1 endogenous retrovirus, HERVE subfamily

Description

Associated long terminal repeat is LTR2. The gag and pol genes are ~40% similar to Moloney murine leukemia virus (MoMuLV). Some unique characteristics of the endogenous human retroviral DNA included a tRNA Glu primer binding site separated from the 5' LTR by a pentanucleotide and a putative env sequence which does not appear to overlap the C terminus of pol and has virtually no homology with the env gene of known infectious retroviruses. The reconstructed (though still pseudogenic) gene boundaries are: Gag: 571-2094, Pol: 2095-5655, Env: 5678-7750.

References

  1. Distinctive termini characterize two families of human endogenous retroviral sequences.
    Steele PE, Rabson AB, Bryan T, Martin MA;
    Science 1984;225:943-947 Pubmed

  2. Nucleotide sequence of a full-length human endogenous retroviral segment.
    Repaske R, Steele PE, O'Neill RR, Rabson AB, Martin MA;
    J Virol 1985;54:764-772 Pubmed

Classification

Accession Name Wikipedia
Type Retrotransposon Article
Class LTR Article
Superfamily ERV1 Article

Hit Statistics

The model is 7813 positions long. The average length of non-redundant hits to the model is 2279.2. This table shows the number of hits above score thresholds:

Species Gathering Trusted
non-redundant all hits non-redundant all hits
Homo sapiens 219 6099 202 4081

External Database Links

  • Repbase : HERVE [Requires Repbase registration]